The human respiratory system faces numerous challenges nowadays. With diseases like Chronic Obstructive Pulmonary Disease (COPD), pulmonary fibrosis, and Acute Respiratory Distress Syndrome (ARDS) being major health concerns and one of the leading cause of death globally, according to WHO. Traditional treatments often focus on managing symptoms rather than addressing the underlying cause, underscoring the urgent need for innovative solutions that repair damaged lung tissue at a fundamental level.
According to the researchers from University of Pittsburgh School of Medicine (USA), Mesenchymal stem cells (MSCs) possess several valuable attributes that make them a promising option in lung repair. They secrete cytokines and growth factors, migrate to damaged sites upon administration, and can ‘rescue’ cells by transferring functional mitochondria. Additionally, MSCs enhance the repair process by promoting angiogenesis, the formation of new blood vessels, which improves oxygen supply to the damaged tissue and accelerates healing. These features position MSCs as a potential therapeutic agent for treating chronic lung diseases with high morbidity and mortality rates, such as idiopathic pulmonary fibrosis (IPF), COPD, and obstructive bronchiolitis (OB).
Stem cells have the unique ability to regenerate damaged lung tissue. By differentiating into functional lung cells, they can help restore normal respiratory function and repair the
https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death
structural damage caused by diseases like COPD, asthma and pulmonary fibrosis, as well as improve overall lung function.
Chronic lung conditions often involve significant inflammation. Stem cells can reduce inflammation by secreting anti-inflammatory factors, which helps alleviate symptoms and slows disease progression.
Advances in stem cell research allow for the development of personalized treatments tailored to individual patients’ needs. By using Mesenchymal Stem Cell derived from a patient’s own fat tissues, therapies can be customized to address specific lung issues with minimal risk of rejection.
Stem cell technology represents a transformative approach to treating lung diseases by addressing the root causes of damage and promoting tissue regeneration. Our Regenerative Medicine Department is leading the way in integrating groundbreaking therapies, with the goal to provide patients with access to state-of-the-art regenerative therapies that can significantly enhance their quality of life, with the promise of offering new hope and improving outcomes for patients with chronic and acute lung conditions.
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